Metabolome informs about the chemical exposome and links to brain health

Metabolomic profiles of small molecules in biospecimens may reflect the impact of environmental exposures on human health.

• The metabolome summarizes the effects of the chemical exposome, diet, gut microbiome, and genome.
• Metabolic changes in exposome studies could provide insights into pathways associated with cancer, diabetes, heart disease, and neurological conditions.
• There is a limited number of human cohort studies that integrate both metabolomic and exposomic profiles in the context of neurological conditions.
• Environmental exposures to chemicals like bisphenols, phthalates, PCBs, and PFAS may have significant effects on the brain and gut-brain axis.
• Chronic exposure to certain environmental chemicals is associated with an increased risk of Alzheimer's disease by influencing relevant biochemical mechanisms.

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