St. John's Wort may reduce depression-like behaviors by affecting gut bacteria, inflammation, and cell signaling

Metagenomic sequencing and network pharmacology were used to explore the role of gut microbiota in the effects of Hypericum perforatum on depressive-like behaviors.

• The relationship between Hypericum perforatum and gut microbiota may be significant in alleviating depressive-like symptoms.
• A focus on gut-brain interactions suggests potential pathways influencing mood regulation.
• Understanding the gut-brain axis could provide insights into the mechanisms behind the antidepressant effects of herbal treatments.

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