Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics

Feb 6, 2025International journal of pharmaceutics

Current uses of metal-organic frameworks for delivering genetic material and treatments

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Abstract

Metal-organic frameworks (MOFs) may enhance nucleic acid delivery due to their unique properties.

MOFs are highly ordered, porous nanomaterials formed by metal ions and organic ligands.
Their structural porosity allows for high loading efficiency and stability in nucleic acid delivery.
Different methods for loading nucleic acids into MOFs are compared within the review.
A systematic classification of nucleic acid types loaded in MOFs and their applications is provided.
MOF-mediated nucleic acid treatments may be effective in combination with other therapies for malignant tumors.
The review discusses challenges and potential opportunities for MOF technology in clinical applications.

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Nucleic acid drugs utilize DNA or RNA molecules to modulate abnormal gene expression or protein translation in cells, enabling precise treatment for specific conditions. In recent years, nucleic acid drugs have demonstrated tremendous potential in vaccine development and treating genetic disorders. Currently, the primary carriers for clinically approved nucleic acid therapies include lipid nanoparticles and viral vectors. Beyond that, metal-organic frameworks (MOFs) are highly ordered, porous nanomaterials formed through the self-assembly of metal ions and organic ligands via coordination bonds. Their porosity structure offers great loading efficiency, stability, tunability, and biocompatibility, making them an attractive option for nucleic acid delivery. Given the research on MOFs as nucleic acid carriers has garnered significant attention in recent years, this review provides an overview of the therapeutic strategies and advancements in MOF-mediated nucleic acid delivery. The unique properties of various MOF carriers are introduced, and different approaches for nucleic acid loading are parallelly compared. Moreover, a systematic classification based on the type of nucleic acid cargo loaded in MOFs and corresponding applications is thoroughly described. This summary outlines the unique mechanisms through MOFs enhance nucleic acid delivery and emphasizes their substantial impact on therapeutic efficacy. In addition, the utilization of MOF-mediated nucleic acid treatment in combination with other therapies against malignant tumors is discussed in particular. Finally, an outlook on the challenges and potential opportunities of this technology in future translational production and clinical implementation is presented and explored.

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Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics

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