Metformin may improve diabetes-related memory problems by helping cells clear damaged mitochondria through p53 and Parkin pathways

Impaired mitophagy may be a key feature of diabetes-associated cognitive dysfunction (DACD).

• Diabetes-associated cognitive dysfunction is a serious complication of diabetes.
• Emerging evidence links impaired mitophagy to the pathology of DACD.
• Metformin has been shown to have both blood sugar-lowering and cognitive-enhancing effects.
• The exact mechanisms by which metformin affects mitophagy and DACD are not fully understood.

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