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Abstract
Metformin may provide a safer non-opioid treatment strategy for pain management.
- Pain management is challenging due to the limited effectiveness and side effects of current analgesics.
- Metformin has emerging evidence suggesting potential pain-relief properties.
- Proposed mechanisms for metformin's analgesic effects include activation of pathways that inhibit processes involved in pain sensitization.
- A systematic review is planned to assess the effectiveness and safety of metformin for treating or preventing pain in adults.
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