Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue

Dec 8, 2020Anticancer research

Methylated RNA and RNA-Modifying Enzymes as New Predictors in Removed Liver Cancer and Nearby Liver Tissue

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Abstract

The expression of mA demethylases FTO and ALKBH5 is significantly lower in hepatocellular carcinoma (HCC) than in non-cancerous tissues (both p<0.001).

  • Global mA quantification showed no significant difference between HCC and non-cancerous liver tissue.
  • Lower expression levels of the mA demethylases FTO and ALKBH5 in HCC could suggest their role in cancer development.
  • In non-cancerous tissues, low ALKBH5 expression is associated with worse recurrence-free survival (median of 16.3 vs. 38.9 months, p=0.001).
  • These findings may indicate that mA and its demethylases in surrounding non-cancerous tissues are involved in HCC malignancy after surgical resection.

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