Archives of biochemistry and biophysics

Inflammation and cell cleanup responses linked to METTL3/FOSL1 and m6A regulation in sepsis-related sudden kidney injury

Updated

Abstract

Sepsis-induced acute kidney injury (S-AKI) is characterized by tubular damage, inflammation, and dysregulated autophagy.

  • N6-methyladenosine (m6A) RNA modification plays a role in regulating mRNA stability and responses to cellular stress.
  • The specific mechanisms of m6A modification in the context of S-AKI are not fully understood.
  • Further investigation is needed to clarify how m6A might influence the pathology of S-AKI.

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