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MGMT gene promoter methylation in pediatric glioblastomas
MGMT Gene Silencing in Childhood Brain Tumors Called Glioblastomas
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Abstract
MGMT gene promoter methylation was observed in 50% of pediatric glioblastomas.
- The frequency of MGMT gene promoter methylation in pediatric glioblastomas is similar to that seen in adult patients.
- p53 protein expression was detected in 60% of pediatric glioblastoma cases.
- Seventy percent of cases with methylated MGMT promoter also showed p53 immunopositivity.
- This study represents only the second investigation into MGMT gene promoter methylation status in pediatric glioblastomas.
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