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Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
Lack of MGMT protein and changes in its gene control predict response to temozolomide
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Abstract
The MGMT protein was detected in all temozolomide-resistant cell lines.
- TMZ-sensitive cell lines showed no detectable MGMT protein.
- MGMT promoter methylation was predictive of TMZ sensitivity in 100% of six analyzed glioblastoma multiforme cell lines.
- MS-MLPA predicted TMZ sensitivity in 56% of 16 cell lines.
- qMSP results aligned well with TMZ sensitivity in 92% of 12 glioma cell lines.
- MGMT protein expression is associated with resistance to the drug temozolomide.
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