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Abstract
Mice lacking vasopressin receptors V1a and V1b demonstrated immediate reentrainment of circadian rhythms to phase-shifted light-dark cycles.
- Circadian rhythms of behavior, clock gene expression, and body temperature adjusted quickly to new light-dark cycles in V1a(-/-)V1b(-/-) mice.
- Despite rapid adjustment, behavior in these mice remained linked to their internal circadian clock, which functioned normally under standard conditions.
- Experiments indicated that communication between neurons, regulated by V1a and V1b, may help the suprachiasmatic nucleus resist disruptions from external changes.
- Blocking V1a and V1b in wild-type mice led to faster recovery from jet lag, suggesting vasopressin signaling could be targeted for treating circadian misalignments.
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