Molecules (Basel, Switzerland)Jul 28, 2026

Effects of a Micelle-Based Resveratrol Formula on Brain Growth Support and Nerve Signaling in Healthy Rats

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 3, 2026

Abstract

Micellar encapsulation of resveratrol (mRVT) significantly enhances its neurochemical effects compared to pure resveratrol.

Both mRVT and pure resveratrol treatments reduced hippocampal acetylcholinesterase activity and elevated acetylcholine levels in the cortex and hippocampus.
mRVT treatment produced a more pronounced increase in acetylcholine levels in the hippocampus compared to pure resveratrol.
Compared to pure resveratrol, mRVT led to greater increases in noradrenaline and serotonin levels in both the cortex and hippocampus.
Both treatments comparably upregulated brain-derived neurotrophic factor (BDNF) and phosphorylated cyclic AMP response element-binding protein (pCREB) levels in the cortex.
mRVT uniquely reduced cortical lipid peroxidation, an effect not observed with pure resveratrol treatment.

Simplified

Encapsulation of resveratrol (RVT), a natural polyphenol, in mixed Pluronic F127/P123 micelles (mRVT) has enhanced its pharmacological efficacy in experimental dementia models. The aim of this study was to evaluate neurochemical and behavioral parameters of mRVT treatment in healthy subjects. For this purpose, pure RVT and mRVT (both at 10 mg/kg i.p.) were applied for 9 consecutive days in healthy male Wistar rats. Memory performance was assessed using the novel object recognition and passive avoidance tests. Neurotransmitter levels, neurotrophic and transcription factors, and oxidative stress markers were quantified in the cortex and hippocampus using enzyme-linked immunosorbent assay kits. Our results showed that neither treatment altered locomotor activity or short-term memory performance. Both RVT and mRVT treatments reduced hippocampal acetylcholinesterase activity to a similar extent and elevated acetylcholine levels in the cortex and hippocampus, with mRVT producing significantly more pronounced effect in the hippocampus. Compared to pure RVT, mRVT elicited a greater increase in noradrenaline and serotonin levels in both brain regions and comparably upregulated BDNF and pCREB protein levels in the cortex. Furthermore, mRVT uniquely reduced cortical lipid peroxidation-an effect absent with pure RVT treatment. These findings demonstrate that micellar encapsulation substantially amplifies the neurochemical efficacy of resveratrol under physiological conditions without adverse behavioral effects.

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Effects of a Micelle-Based Resveratrol Formula on Brain Growth Support and Nerve Signaling in Healthy Rats

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