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Effects of micro- and nano-plastics exposure on cellular senescence: an overview
How Tiny Plastic Particles Affect Cell Aging: An Overview
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Abstract
Micro- and nano-plastics (MNPs) have been detected in multiple human organs.
- MNPs can enter the human body through diet, inhalation, and skin contact.
- Once inside, MNPs may distribute through the bloodstream to various tissues.
- Exposure to MNPs is linked to cellular senescence, which increases the risk of age-related diseases.
- The mechanisms connecting MNPs to cellular senescence involve oxidative stress and DNA damage.
- Signaling pathways associated with MNPs-induced cellular senescence include eNOS/SIRT1, cGAS-STING, and NF-κB.
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