From exposure to neurotoxicity induced by micro-nanoplastics with brain accumulation and cognitive decline

Oct 4, 2025Ecotoxicology and environmental safety

Brain buildup of tiny plastics linked to nerve damage and memory loss

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Abstract

Micro-nanoplastics (MNPs) are capable of penetrating the blood-brain barrier and accumulating in critical brain regions.

MNPs have been found in key areas of the brain, such as the hippocampus and prefrontal cortex, which are important for memory and decision-making.
Chronic exposure to MNPs in animal studies may lead to cognitive deficits and behaviors similar to those seen in neurodegenerative diseases.
The adverse effects of MNPs are associated with oxidative stress, neuroinflammation, and synaptic dysfunction.
MNPs may also contribute to cerebrovascular problems, including endothelial dysfunction and small vessel injury, potentially raising the risk of cognitive decline and stroke.
Current evidence highlights significant knowledge gaps regarding MNPs' neurotoxic effects and the need for further investigation and public health measures.

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The pervasive presence of micro-nanoplastics (MNPs) in the human environment has raised concerns regarding their potential implications for neurological health. Once regarded as biologically inert, MNPs are now recognised as capable of penetrating the blood-brain barrier (BBB) or entering the central nervous system (CNS) through sensory neuronal pathways. Recent studies have demonstrated that MNPs can accumulate in key brain regions, such as the hippocampus and prefrontal cortex, which are critical for memory, emotion, and executive function. Animal experiments have revealed that chronic exposure to MNPs may result in cognitive deficits, behavioral disturbances, and pathological features resembling neurodegenerative diseases. The mechanisms underlying these adverse effects are likely multifaceted, involving oxidative stress, persistent neuroinflammation, synaptic dysfunction, and disturbances of the gut-brain axis. In addition to their direct neuronal effects, MNPs may also impair cerebrovascular health by promoting endothelial dysfunction, vascular calcification, and small vessel injury, further increasing the risk of cognitive decline and stroke. This review synthesizes current evidence from environmental exposure to neural accumulation, providing mechanistic insights into MNPs-induced neurotoxicity. The review also highlights critical knowledge gaps and emphasizes the urgent need for further research and public health interventions to address this emerging environmental threat.

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From exposure to neurotoxicity induced by micro-nanoplastics with brain accumulation and cognitive decline

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