Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype

Significant differences in microbial composition were observed across age groups and constipation subtypes in functional constipation.

• The young group exhibited higher anal resting and squeeze pressures compared to middle-aged and older groups.
• Microbial richness and diversity were notably lower in the older group than in the younger and middle-aged groups.
• The young group's gut microbiota was enriched in bacteria that enhance sphincter tone and reduce intestinal movement.
• The older group had higher levels of beneficial bacteria that produce short-chain fatty acids.
• The middle-aged group showed an increase in pro-inflammatory and pathogenic bacteria.
• Microbial richness and diversity were greater in patients with slow-transit constipation than in those with defecatory disorder.

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