Full text is available at the source.
Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice
Gut bacteria chemicals called indoles may activate a brain receptor and reduce brain inflammation in Alzheimer's model mice
AI simplified
Abstract
Microbiota-derived indoles may alleviate neuroinflammation in Alzheimer's disease models.
- Indoles derived from gut microbiota can prevent the accumulation of amyloid-beta and hyperphosphorylation of Tau, which are key features in Alzheimer's disease.
- Indoles enhance synaptic plasticity and improve cognitive and behavioral abilities in APP/PS1 mice.
- An imbalance in indole-producing bacteria and a deficiency in tryptophan were observed in male APP/PS1 mice.
- Indoles upregulated the production of the aryl hydrocarbon receptor and inhibited the NF-κB signaling pathway.
- These compounds reduced the release of inflammatory cytokines, thereby alleviating the inflammatory response associated with Alzheimer's disease.
AI simplified