Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future

Aug 14, 2020Cell host & microbe

What We Know and Don’t Know About Gut Bacteria and Fatty Liver Disease

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Abstract

Changes in the gut microbiota are linked to the development and progression of alcohol-associated and non-alcoholic fatty liver disease.

  • Microbes in the intestine play a dual role in liver health, maintaining homeostasis while also acting as a source of pathogens.
  • Alterations in gut microbiota composition may promote chronic liver diseases, particularly in Western populations.
  • Microbial products are implicated in the pathogenesis of liver diseases, suggesting a complex relationship between gut bacteria and liver function.
  • Potential microbial biomarkers could aid in identifying specific liver disease subtypes.
  • Manipulating the gut microbiota may offer new treatment strategies for fatty liver diseases.

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