Studying how gut microbes influence brain decline using zebrafish

Dysfunction in the microbiota-gut-brain axis is closely linked with the development of neurological disorders.

• The microbiota-gut-brain axis (MGBA) facilitates communication between the gut microbiome and the central nervous system.
• Gut dysbiosis can lead to increased intestinal inflammation and altered barrier function.
• Elevated levels of pro-inflammatory cytokines and immune cell infiltration into the brain are associated with neuroinflammation.
• Neuroinflammation may contribute to neuronal defects and behavioral issues.
• Zebrafish are proposed as a valuable model for studying MGBA interactions and their implications in neurological conditions.

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