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Abstract
Ischemic stroke damage severity increases markedly with age.
- Age is closely tied to the physical and functional deterioration of the neurovascular unit.
- Microglia and astrocyte interactions significantly influence age-related vascular frailty.
- With ongoing metabolic stress, microglia may shift toward a senescent state, becoming drivers of inflammation.
- Dysfunctional microglia can induce astrocytes into a neurotoxic state through specific factors.
- Chronic neuroinflammation caused by microglia-astrocyte interactions may disrupt the blood-brain barrier and lead to neurovascular decoupling.
- Cellular abnormalities could result in impaired microvascular recanalization and progressive white matter damage.
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