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Microglia depletion alleviates the disruptions in circadian rhythms and anxiety caused by bmal1 deficiency
Removing immune brain cells helps fix daily rhythm and anxiety problems caused by bmal1 deficiency
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Abstract
Disruptions in circadian rhythms were observed in bmal-/- mice, characterized by increased microglia numbers.
- Microglial activation was associated with altered activity patterns in bmal-/- mice.
- Inhibition of microglia using PLX5622 improved behavioral performance in bmal-/- mice during specific tests.
- Microglia inhibition restored structural and functional abnormalities in neurons of bmal-/- mice.
- Dendritic spine reduction and impaired long-term potentiation (LTP) were observed in bmal-/- mice.
- Normalization of proinflammatory cytokine levels (IL-1β and TNF-α) occurred following PLX5622 treatment.
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