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Abstract
selectively regulate lipid accumulation associated with Alzheimer's disease pathology in both mouse models and human brains.
- Abnormal lipid metabolism is observed in Alzheimer's disease, but its role in disease progression is unclear.
- Microglia influence lipid processing during Alzheimer's disease, impacting disease pathology.
- A buildup of arachidonic acid-containing bis(monoacylglycero)phosphate is identified in response to amyloid plaques, dependent on microglial activity and the AD risk gene GRN.
- Lysophosphatidylcholine and lysophosphatidylethanolamine accumulate independently of microglia, correlating with astrocyte activation and oxidative stress.
- Dysregulated lipid metabolism in Alzheimer's disease is linked to specific brain cell types and molecular pathways.
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