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Abstract
Loss of the major circadian rhythm regulator, Bmal1, in microglia induced a proinflammatory state and excessive synapse pruning in adolescent male mice.
- The circadian clock influences how microglia refine synapses during key neurodevelopmental periods.
- Changes in microglial function are linked to sex differences, with notable effects observed in male mice.
- A proinflammatory state in microglia is associated with the loss of Bmal1, leading to altered synaptic pruning.
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