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Abstract
Microglial mitophagy is disrupted by multiple factors in Alzheimer's disease, which may amplify neuroinflammation.
- Chronic neuroinflammation is a key feature of Alzheimer's disease.
- Microglia play a crucial role in regulating the pathophysiology of Alzheimer's through their immune functions.
- Effective mitophagy helps clear damaged mitochondria and limits the release of mitochondrial damage-associated molecular patterns (DAMPs).
- In Alzheimer's disease, factors such as amyloid-beta deposition and tau pathology interfere with mitophagy processes.
- Dysfunctional mitophagy may lead to increased neuroinflammation through the release of mitochondrial DAMPs and altered cellular signaling.
- Current therapeutic strategies aim to restore mitophagy, which could influence neuroinflammatory responses and Alzheimer's-related processes.
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