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Abstract
Concentrations of microplastics and nanoplastics in human brain tissue can reach 4917 μg/g, with levels up to 10-fold higher in individuals with dementia.
- Microplastics and nanoplastics are detected in human brain tissue, suggesting potential health risks.
- These particles may cross the blood-brain barrier and olfactory pathway, impacting central nervous system function.
- Exposure is associated with neuroinflammation and neurodegeneration, linked to mechanisms such as disruption of brain barrier integrity and activation of inflammatory pathways.
- Oxidative stress and mitochondrial dysfunction are potential consequences of plastic particle exposure, which could affect brain cell health.
- Evidence indicates that exposure may promote the aggregation of proteins involved in Alzheimer's and Parkinson's diseases.
- Indirect neurotoxicity through the gut-brain axis is also a concern, highlighting the complexity of plastic exposure effects.
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