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Dual role of MIF in aging and cellular senescence
The two roles of MIF in aging and cell aging
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Abstract
Macrophage migration inhibitory factor (MIF) is associated with chronic inflammation and age-related diseases.
- MIF has distinct mechanisms of secretion and signaling that vary by cellular context.
- Extracellular MIF may enhance chronic inflammation via interactions with specific receptors.
- Intracellular MIF is linked to processes such as cell growth, DNA repair, and autophagy through its antagonism of p53.
- Oxidized MIF could serve as a marker for age-related diseases.
- Evidence suggests MIF signaling can have both protective and harmful effects depending on the disease context.
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