Molecular biology reports

miR-486 reduces heart injury after blood flow returns by blocking cell death and self-cleaning through the FOXO1/PTEN/AKT/mTOR pathway

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated

Abstract

The expression of miR-486 is downregulated in ischaemic myocardium.

  • Myocardial ischaemia/reperfusion injury (MIRI) currently lacks effective therapeutic interventions.
  • miR-486 is a microRNA that is enriched in heart tissue.
  • The functional role of miR-486 in MIRI is not well understood.
  • Further investigation is needed to clarify the molecular mechanisms associated with miR-486 in this context.

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