Zeitschrift fur Gerontologie und GeriatrieJul 22, 2026

Miscommunication between cells in aging and long-term inflammation

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jul 23, 2026

Abstract

Aging is associated with a shift from coordinated to disrupted cell communication.

Disrupted communication among cells is primarily caused by senescent cells and their secretions.
The senescence-associated secretory phenotype (SASP) contributes to systemic aging and inflammation.
Reducing the number of senescent cells using senolytics may help restore communication.
Inhibiting the SASP with senomorphics could also address the consequences of cellular aging.
Successful outcomes observed in animal studies support the potential for translation to human applications.

Simplified

Intercellular communication refers to the various ways through which cells communicate with one another and exchange a wide range of messages. Aging leads to a shift from coordinated signal transmission to disrupted, uncoordinated communication, which is primarily caused by senescent cells and their secretome (senescence-associated secretory phenotype, SASP). This breakdown drives systemic aging and leads to dysfunction and inflammatory processes throughout the body. A translational approach now involves either reducing the number of senescent cells using senolytics or inhibiting their SASP using senomorphics. This approach, which has been successful in animal studies, is now to be translated to humans.

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Competing interests

No competing interests reported.

PubMed

Miscommunication between cells in aging and long-term inflammation

Abstract

Full Text

Funding

Competing interests

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