Genes related to energy production and programmed cell death may be disrupted in spontaneous preterm birth

Multiple programmed cell death modalities are closely implicated in spontaneous preterm birth.

• Apoptosis, autophagy, and ferroptosis are types of programmed cell death associated with spontaneous preterm birth.
• Mitochondria are central to regulating these programmed cell death pathways and are crucial for cellular stress responses.
• There is a lack of comprehensive studies that integrate mitochondria-related genes and programmed cell death-related genes in the context of spontaneous preterm birth.

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