How Mitochondria and Immune Cells Interact During Sepsis at Different Stages: Linking Metabolic Changes, Organ Damage, and Treatment Options

Mitochondria may play a critical role in the immune dysfunction observed in sepsis.

• Sepsis is associated with dysregulated host responses to infection, leading to immune dysfunction and multi-organ injury.
• Disrupted communication between mitochondria and macrophages could create a self-amplifying loop that drives excessive inflammation.
• Key metabolic pathways, such as glycolysis and oxidative phosphorylation, may influence how macrophages activate and function during sepsis.
• Mitochondrial quality control processes, including mitophagy and mitochondrial biogenesis, are implicated in the progression of sepsis.
• Targeting the interaction between mitochondria and macrophages may present new therapeutic options for managing sepsis.

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