Mitochondria-linked processes in lung blood pressure disease: From changes in cell metabolism to blood vessel and heart damage

Mitochondria may play a critical role in pulmonary hypertension by acting as signaling hubs that influence various cellular processes.

• Mitochondrial signaling abnormalities could contribute to pulmonary hypertension by promoting the proliferation of pulmonary artery smooth muscle cells.
• Endothelial dysfunction may be linked to mitochondrial signaling disturbances in pulmonary hypertension.
• Resistance to cell death in this condition is associated with altered mitochondrial signaling pathways.
• Inflammatory activation in pulmonary hypertension may be influenced by mitochondrial signaling mechanisms.
• Right ventricular metabolic remodeling is potentially connected to the dysfunctional signaling of mitochondria.

Simplified