Mitochondria trigger two processes that cause cells to release aging-related signals

Mitochondrial citrate metabolism drives inflammation in senescent cells.

• Senescent cells exhibit a long-lasting inflammatory profile that affects tissue health.
• A specific metabolic process involving citrate in mitochondria is linked to increased inflammation.
• This inflammation pathway operates independently of immune signaling triggered by mitochondrial DNA.
• However, it works alongside mitochondrial DNA signaling to enhance the inflammatory response.

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