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Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy
Mitochondrial damage helps activate inflammation by Pseudomonas aeruginosa and is reduced by cellular cleanup
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Abstract
Infection with Pseudomonas aeruginosa activates the NLRC4 inflammasome through mitochondrial damage and mitochondrial DNA release.
- Pathogenic bacteria use a specialized secretion system to activate the NLRC4 inflammasome.
- Mitochondrial damage during infection leads to increased production of reactive oxygen species and release of mitochondrial DNA.
- Inhibition of mitochondrial reactive oxygen release or degradation of mitochondrial DNA prevents NLRC4 inflammasome activation.
- Macrophages without mitochondria do not activate the NLRC4 inflammasome upon infection.
- Autophagy reduces NLRC4 inflammasome activation by removing damaged mitochondria.
- Mitochondrial DNA can activate the NLRC4 inflammasome directly, with oxidation enhancing this activation.
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