Full text is available at the source.
Abstract
Mitochondrial dysfunction is associated with various neurological and neurodegenerative disorders.
- The brain's high metabolic demands make it particularly vulnerable to impaired mitochondrial function.
- Impaired mitochondria can lead to oxidative stress, disrupted calcium balance, and overactive immune responses in the brain.
- Mitochondrial disturbances are linked to neuronal damage, synaptic dysfunction, and cognitive decline.
- Mitochondrial-derived vesicles (MDVs) are released from stressed mitochondria and play a role in maintaining mitochondrial health.
- MDVs facilitate communication between cells and may contribute to signaling related to neuroinflammation.
- The review discusses the potential of MDVs in diagnosis and therapy for neurological disorders, as well as current limitations.
Simplified