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Abstract
Mitochondria in human-induced pluripotent stem-cell-derived vascular smooth muscle cells increased in number and changed shape after differentiation.
- Mitochondria transitioned from a perinuclear to a cytoplasmic distribution during the differentiation process.
- The shape of mitochondria changed to elongated tubular structures with a more uniform matrix density.
- Transcriptomic analysis showed an upregulation of genes associated with mitochondrial fusion, autophagy, and energy production following differentiation.
- Increased intracellular ATP content was observed, indicating a potential rise in cellular energy capacity.
- Multiomics analysis suggested activation of mitochondrial oxidative metabolism pathways, including those for energy production from various nutrients.
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