We can’t show the full text here under this license. Use the link below to read it at the source.
Association of mitochondrial genetic background with pS65-Ub in Lewy body disease
Link between mitochondrial genes and a specific protein marker in Lewy body disease
AI simplified
Abstract
In a study of 514 Lewy body disease brains, no individual mitochondrial DNA haplogroup was significantly associated with levels of the mitophagy marker .
- Mitophagy is a process that helps remove damaged mitochondria to maintain cellular health.
- Previous findings indicated a significant association between apolipoprotein E ε4 and pS65-Ub levels in the hippocampus of Lewy body disease.
- The investigation into mitochondrial DNA variation and its effect on pS65-Ub levels did not find significant associations after correcting for multiple comparisons.
- Mitochondrial DNA haplogroup V showed a nominal association with pS65-Ub levels, but this was not replicated in an independent cohort.
- The results suggest that mitochondrial dysfunction may not be solely explained by major mitochondrial DNA variations.
AI simplified
Key numbers
78 years
Median Age at Death
Age at death for the primary series of 514 LBD cases.
200 of 514
Heteroplasmy Count
Number of samples with at least 1 heteroplasmy in the primary series.
0.021
Nominal Association with Haplogroup V
P-value indicating a nominal association between haplogroup V and lower levels in the primary series.