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Abstract
NCLX may play a crucial role in both pathological and physiological aging of the brain.
- NCLX is important for mitochondrial calcium regulation, which is associated with various brain pathologies.
- Its role in healthy aging of the central nervous system (CNS) is largely unexplored.
- NCLX interacts with partners like TMEM65 and is linked to pathways involved in metabolism, hypoxia, inflammation, and oxidative stress.
- Different functions of NCLX in neurons and glial cells may influence brain aging processes.
- A better understanding of NCLX's mechanisms and cell-specific roles could inform targeted interventions.
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