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Abstract
Age-related skeletal muscle decline may involve mitochondrial dysfunction as a central mechanism.
- Skeletal muscle decline is linked to frailty and loss of independence in older adults.
- Type II muscle fibers experience selective atrophy, contributing to functional impairment.
- Mitochondrial dysfunction affects energy production and regulatory processes in aged muscle.
- Chronic oxidative stress and defective quality control are associated with impaired muscle homeostasis.
- A decline in mitochondrial respiratory capacity is observed independently of lifestyle factors.
- Quality control mechanisms like mitochondrial biogenesis and mitophagy are critical for muscle health.
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