JACC. Basic to translational science

Problems in Mitochondrial Cleanup and Movement in Atherosclerosis

Updated

Abstract

Mitochondrial health is essential for maintaining cardiac function.

  • Mitophagy, the selective degradation of damaged mitochondria, is crucial for maintaining mitochondrial quality.
  • Proper regulation of mitophagy is associated with supporting cardiac health.
  • Imbalances in mitophagy may contribute to the onset and progression of cardiovascular conditions.
  • The cardioprotective potential of mitophagy is examined in the context of atherosclerotic disease.
  • Mitophagy is closely linked to mitochondrial dynamics, affecting both macrovascular and microvascular dysfunction.
  • Current gaps in knowledge and key questions remain to guide future research in cardiovascular biology.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Funding Support and Author Disclosures Dr Widlansky is supported by HL144098, HL173778, K24HL152143, R38HL167238, KL2TR001438, and AHA9639591. Ms Wilcox is supported by 25PRE1360839. Dr Widlansky has an ownership stake in Sanacor, a company focused on developing mitochondrial fission and fusion inhibitors to treat atherosclerotic and microvascular diseases. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free