Full text is available at the source.
Abstract
Impairment of mitochondrial quality control is associated with metabolism-associated steatotic liver disease (MASLD).
- Reduced mitophagy may contribute to mitochondrial dysfunction in MASLD.
- Increased mitochondrial fission and decreased fusion are observed in this condition.
- Impaired mitochondrial biogenesis is linked to the progression of MASLD.
- Pathological mechanisms such as hepatocyte apoptosis and pyroptosis are activated by factors like free fatty acids and oxidative stress.
- Potential therapeutic strategies include enhancing autophagy and regulating mitochondrial dynamics.
Simplified