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Mitochondrial‐Targeted Copper Delivery for Cuproptosis‐Based Synergistic Cancer Therapy
Delivering Copper to Mitochondria for Combined Cancer Treatment Using Copper-Induced Cell Death
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Abstract
A metal-organic framework-based nanoplatform (ZCProP) can responsively release copper ions at mitochondria.
- The ZCProP nanoplatform targets mitochondrial respiration by releasing copper ions and prodigiosin.
- This release promotes the aggregation of specific proteins and leads to cell cuproptosis.
- Copper ions work alongside prodigiosin to induce mitochondrial dysfunction and DNA damage.
- ZCProP depletes glutathione, which may enhance cuproptosis and trigger ferroptosis by inhibiting an anti-ferroptosis protein.
- The designed nanoplatform demonstrates promising therapeutic efficacy in cancer treatment through a cuproptosis-mediated effect.
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