Full text is available at the source.
Abstract
Mitophagy is involved in multiple cardiovascular diseases, including heart failure and myocardial infarction.
- The heart's energy demands make it reliant on mitochondrial energy production and metabolic balance.
- Mitophagy, a selective process for removing damaged mitochondria, is important for maintaining cardiac cell function.
- Evidence suggests mitophagy can occur through both Parkin-dependent and -independent pathways.
- Natural compounds and small-molecule agents may help reduce heart damage and enhance function by influencing mitophagy.
- Further research is needed to clarify the specific molecular mechanisms and regulatory networks of mitophagy in different cardiovascular conditions.
Simplified