Removal of damaged mitochondria and cell cleanup in heart damage caused by doxorubicin: how they interact and potential treatments

Doxorubicin-induced cardiotoxicity (DIC) is associated with various cardiac complications, including subclinical myocardial injury and heart failure.

• DIC may manifest as arrhythmias, left ventricular dysfunction, or cardiomyopathy.
• The drug disrupts organelle function through DNA damage and stress responses.
• Oxidative stress and imbalances in iron and calcium levels are implicated in DIC.
• Mitochondrial and endoplasmic/sarcoplasmic reticulum injury are central features of DIC.

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