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Abstract
Impaired mitophagy may increase neuronal susceptibility to ferroptosis in Alzheimer's disease.
- Alzheimer's disease is characterized by amyloid-β plaques and hyperphosphorylated tau protein tangles.
- Mitophagy is the process that clears damaged mitochondria, while ferroptosis is a type of cell death linked to iron.
- Impaired mitophagy can disrupt the balance of redox and iron levels within cells.
- Increased susceptibility to ferroptosis may result from the disruption caused by impaired mitophagy.
- Ferroptosis can lead to further mitochondrial dysfunction through processes like lipid peroxidation.
- This interplay creates a self-amplifying cycle that may accelerate the progression of Alzheimer's disease.
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