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Mitophagy is responsible to ionizing radiation but plays a very limited role in the radiosensitivity of adenocarcinoma cells
Mitophagy responds to ionizing radiation but has little impact on how sensitive adenocarcinoma cells are to radiation
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Abstract
Exposing adenocarcinoma cells to 5 Gy X-ray enhanced mitophagy activity and the expression of some mitophagy receptors.
- Ionizing radiation induces damage not only in cell nuclei but also in mitochondria.
- Mitophagy, the process of degrading impaired mitochondria, responds to ionizing radiation.
- Pharmacological inhibition of mitophagy did not significantly alter the radiosensitivity of HCT116 and A549 cells.
- Molecular targeting to inhibit mitophagy through BNIP3L knockdown also did not significantly change radiosensitivity, despite reduced mitophagy activity.
- Data suggest that while mitophagy is activated by ionizing radiation, it plays a limited role in the radiosensitivity of adenocarcinoma cells.
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