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Mitophagy in neurodegeneration and aging
Removal of damaged cell power sources in brain aging and neurodegenerative diseases
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Abstract
Mitochondrial dysfunction is linked to age-related diseases, including neurodegenerative disorders.
- Maintaining a healthy population of mitochondria is crucial for energy production and cellular function.
- Mitophagy, a process that removes damaged mitochondria, is vital for regulating mitochondrial health.
- Reduced mitophagy may contribute to neurodegenerative diseases like Parkinson's and Alzheimer's.
- There is a complex cellular network that regulates the degradation of mitochondria across different species.
- Mitophagy-inducing compounds, such as NAD precursors and urolithins, may offer potential therapeutic benefits.
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