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Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling
Moderate alcohol intake may promote heat-producing fat cell growth by increasing retinoic acid signals
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Abstract
Moderate alcohol intake (8% in water) prevented body weight gain in male mice over 1 to 4 months.
- Moderate alcohol intake induced the formation of beige adipocytes in white adipose tissue.
- Increased thermogenesis was observed in mice consuming moderate alcohol.
- Decreased serum glucose and triacylglycerol levels were associated with moderate alcohol intake.
- Alcohol intake elevated retinoic acid levels in serum and adipose tissue.
- Blocking retinoic acid receptor signaling in certain adipose progenitors largely abolished alcohol's effects on beige adipocyte formation.
- Moderate alcohol intake prevented obesity and metabolic dysfunction induced by a high-fat diet.
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