Hierarchical Integration of MOF‐Based Nanoplatforms with Electrospun Nanofiber Scaffolds for Spatiotemporally Sustained Diabetic Wound Healing

Oct 9, 2025Advanced healthcare materials

Layered Metal-Organic Framework Nanomaterials Combined with Nanofiber Scaffolds for Controlled Healing of Diabetic Wounds

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

Novel electrospun nanofiber composite membranes (NCMs) enable spatiotemporally controlled release of multiple bioactive components for diabetic wound healing.

Multifunctional dressings are developed that incorporate zeolitic imidazolate framework (ZIF)-based platforms.
The membranes facilitate a staged release, beginning with rapid antibacterial effects and early angiogenesis from ZIF-67 nanoparticles.
Subsequently, a prolonged release of zinc and platelet-derived growth factor-BB from embedded ZIF-8 nanoparticles is observed.
In vitro and in vivo studies indicate effective infection control and improved vascularization.
Accelerated wound healing is associated with the use of these hierarchical metal-organic framework-integrated membranes.

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Currently, diabetic wound dressings continue to exhibit various limitations, hindering their ability to effectively respond to the dynamic and complex microenvironment of diabetic wounds. Particularly, significant challenges remain in developing multifunctional dressings capable of effective multicomponent integration and precise, controlled release of each component. Herein, the novel electrospun nanofiber composite membranes (NCMs) are developed that hierarchically incorporate zeolitic imidazolate framework (ZIF)-based nanoplatforms for spatiotemporally controlled and continuous release of multiple bioactive components, enabling the effective regulation of key factors involved in diabetic wound healing. Specifically, platelet-derived growth factor-BB (PDGF-BB)-loaded ZIF-8 (PZ) nanoparticles (NPs) are embedded within poly(ε-caprolactone)/gelatin (PCL/GT) nanofibers, while ZIF-67 NPs are in situ grown on the nanofiber surface, yielding multifunctional ZIF-67/PZ/PCL/GT (ZPZPG) NCMs. The hierarchical structures facilitate a staged pH-responsive release, wherein initially released Cofrom ZIF-67 NPs rapidly exerts antibacterial effects and promotes early angiogenesis, followed by the prolonged release of Znand PDGF-BB from embedded ZIF-8 NPs, further enhancing antimicrobial activity, neovascularization, fibroblast proliferation, and tissue regeneration. Both in vitro and in vivo studies demonstrate effective infection control, improved vascularization, and accelerated wound healing, underscoring the potential of hierarchical metal-organic framework (MOF)-integrated NCMs as an attractive way to overcome current limitations in diabetic wound therapy. 2+ 2+

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Hierarchical Integration of MOF‐Based Nanoplatforms with Electrospun Nanofiber Scaffolds for Spatiotemporally Sustained Diabetic Wound Healing

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