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Molecular bases of circadian magnesium rhythms across eukaryotes
Molecular causes of daily magnesium level rhythms in plants and animals
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Abstract
A circadian rhythm in intracellular magnesium levels has been identified across multiple eukaryotes.
- Magnesium plays a critical role in cellular metabolism, potentially influencing energy expenditure throughout the day.
- Phylogenetic analysis reveals extensive conservation of ancestral magnesium transport proteins among eukaryotes.
- These conserved proteins may mediate the generation of magnesium rhythms in cells.
- Allosteric regulation of magnesium transport proteins is suggested as a mechanism for the rhythmic patterns observed.
- A reciprocal feedback model is proposed, linking the rhythmic usage of magnesium to its transport activity.
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