Daily molecular rhythms in the brain's central clock and body clocks in mammals

Recent discoveries highlight the complexity of the circadian clock mechanism, involving numerous clock components and regulatory processes.

• New clock components have been identified, enhancing the understanding of circadian rhythm organization.
• Transcription may not be the primary determinant in clock function, suggesting alternative regulatory mechanisms.
• Post-translational modifications of clock proteins introduce additional levels of control over circadian rhythms.
• Chromatin remodeling is crucial for regulating the expression of key components of the circadian clock.

Simplified