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Abstract
Melatonin may influence mitochondrial quality control through various interconnected processes.
- Melatonin is recognized for its roles beyond circadian regulation, particularly in mitochondrial and cytoprotective functions.
- Available evidence indicates that melatonin may regulate reactive oxygen species (ROS), mitochondrial dynamics, and inflammatory signaling.
- In mitochondria, melatonin can reduce oxidative stress from the electron transport chain through both direct and indirect antioxidant actions.
- Experimental studies suggest melatonin may affect mitochondrial fission and fusion processes, as well as mitophagy and biogenesis.
- In reproductive medicine, melatonin has been explored as a potential adjunctive treatment in various conditions, but clinical evidence is mixed.
- Most human studies have focused on reproductive or biochemical outcomes instead of direct biomarkers related to mitochondrial quality control.
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