Full text is available at the source.
Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway
How the mTORC1 Pathway Detects Nutrients Through Molecular and Structural Processes
AI simplified
Abstract
Primary nutrient sensors bind metabolites and undergo changes that signal through pathways controlling growth.
- Amino acids, lipids, sugars, and nucleotides are essential for the regulation of the mTORC1 pathway, which promotes cell growth and proliferation.
- Recent proteomic and bioinformatic studies have identified key nutrient sensors that act upstream of mTORC1.
- Structural biology has revealed how these sensors change shape upon binding metabolites, which initiates signaling responses related to mTORC1.
- This review emphasizes the roles of amino acid and lipid sensors in nutrient detection and their signaling mechanisms.
AI simplified